Names & Taxonomy

Uniprot ID:
Q9UL01
Entry Name:
DSE_HUMAN
Status:
reviewed
Protein Names:
Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2)
Gene Names:
DSE SART2
Gene Names Primary:
DSE
Organism:
Homo sapiens (Human)

Structure

Length:
958
Sequence:
MRTHTRGAPSVFFIYLLCFVSAYITDENPEVMIPFTNANYDSHPMLYFSRAEVAELQLRAASSHEHIAARLTEAVHTMLSSPLEYLPPWDPKDYSARWNEIFGNNLGALAMFCVLYPENIEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQEKFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLVLMNQGYLQEAYLWTKQVLTIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFNINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDGSLKSVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTFFNNVLMFSPAVSKSCFSPWVGQVTEDCSSKWSKYKHDLAASCQGRVVAAEEKNGVVFIRGEGVGAYNPQLNLKNVQRNLILLHPQLLLLVDQIHLGEESPLETAASFFHNVDVPFEETVVDGVHGAFIRQRDGLYKMYWMDDTGYSEKATFASVTYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSIDVQSFTVHGDSQQLDVFIATSKHAYATYLWTGEATGQSAFAQVIADRHKILFDRNSAIKSSIVPEVKDYAAIVEQNLQHFKPVFQLLEKQILSRVRNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQQQQSKSKKNRRAGKRYKFVDAVPDIFAQIEVNEKKIRQKAQILAQKELPIDEDEEMKDLLDFADVTYEKHKNGGLIKGRFGQARMVTTTHSRAPSLSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCILLWLYSSCSQSQC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.
Pathway:
Glycan metabolism; chondroitin sulfate biosynthesis.; Glycan metabolism; heparan sulfate biosynthesis.
Catalytic Activity:
Chondroitin D-glucuronate = dermatan L-iduronate.
Gene Ontology Go:
endoplasmic reticulum
Golgi apparatus
Golgi membrane
integral component of membrane
chondroitin-glucuronate 5-epimerase activity
carbohydrate metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate metabolic process
dermatan sulfate biosynthetic process
glycosaminoglycan metabolic process
heparan sulfate proteoglycan biosynthetic process
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate metabolic process
dermatan sulfate biosynthetic process
glycosaminoglycan metabolic process
heparan sulfate proteoglycan biosynthetic process
small molecule metabolic process
Gene Ontology Molecular Function:
chondroitin-glucuronate 5-epimerase activity
Gene Ontology Cellular Component:
endoplasmic reticulum
Golgi apparatus
Golgi membrane
integral component of membrane
Keywords:
Complete proteome
Disease mutation
Ehlers-Danlos syndrome
Glycoprotein
Isomerase
Membrane
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10679095 14574404 15489334 16505484 23704329