Names & Taxonomy
- Uniprot ID:
- Q9UKU6
- Entry Name:
- TRHDE_HUMAN
- Status:
- reviewed
- Protein Names:
- Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase)
- Gene Names:
- TRHDE UNQ2507/PRO5995
- Gene Names Orf:
- UNQ2507/PRO5995
- Gene Names Primary:
- TRHDE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1024
- Sequence:
- MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVLLSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGKALRH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type II membrane protein.
Function
- Function:
- Specific inactivation of TRH after its release.
- Catalytic Activity:
- Release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa tripeptides and pGlu-|-His-Xaa-Gly tetrapeptides.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 441 441 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
integral component of plasma membrane
aminopeptidase activity
metalloaminopeptidase activity
peptide binding
zinc ion binding
cell-cell signaling
peptide catabolic process
regulation of blood pressure
signal transduction - Gene Ontology Biological Process:
- cell-cell signaling
peptide catabolic process
regulation of blood pressure
signal transduction - Gene Ontology Molecular Function:
- aminopeptidase activity
metalloaminopeptidase activity
peptide binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
integral component of plasma membrane - Keywords:
- Aminopeptidase
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Zinc