Names & Taxonomy
- Uniprot ID:
- Q9UKQ2
- Entry Name:
- ADA28_HUMAN
- Status:
- reviewed
- Protein Names:
- Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (MDC-L)
- Gene Names:
- ADAM28 ADAM23 MDCL
- Gene Names Primary:
- ADAM28
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 775
- Sequence:
- MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
Function
- Function:
- May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 340 340
- Gene Ontology Go:
- extracellular region
integral component of membrane
plasma membrane
metalloendopeptidase activity
metallopeptidase activity
zinc ion binding
spermatogenesis - Gene Ontology Biological Process:
- spermatogenesis
- Gene Ontology Molecular Function:
- metalloendopeptidase activity
metallopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc
Zymogen