Names & Taxonomy

Uniprot ID:
Q9UKQ2
Entry Name:
ADA28_HUMAN
Status:
reviewed
Protein Names:
Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (MDC-L)
Gene Names:
ADAM28 ADAM23 MDCL
Gene Names Primary:
ADAM28
Organism:
Homo sapiens (Human)

Structure

Length:
775
Sequence:
MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.

Function

Function:
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Active Site:
ACT_SITE 340 340
Gene Ontology Go:
extracellular region
integral component of membrane
plasma membrane
metalloendopeptidase activity
metallopeptidase activity
zinc ion binding
spermatogenesis
Gene Ontology Biological Process:
spermatogenesis
Gene Ontology Molecular Function:
metalloendopeptidase activity
metallopeptidase activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular region
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc
Zymogen

Publication

PubMed ID:
10506182 10587367 16421571 15489334 21618342