Names & Taxonomy
- Uniprot ID:
- Q9UK23
- Entry Name:
- NAGPA_HUMAN
- Status:
- reviewed
- Protein Names:
- N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase)
- Gene Names:
- NAGPA
- Gene Names Primary:
- NAGPA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 515
- Sequence:
- MATSTGRWLLLRLALFGFLWEASGGLDSGASRDDDLLLPYPRARARLPRDCTRVRAGNREHESWPPPPATPGAGGLAVRTFVSHFRDRAVAGHLTRAVEPLRTFSVLEPGGPGGCAARRRATVEETARAADCRVAQNGGFFRMNSGECLGNVVSDERRVSSSGGLQNAQFGIRRDGTLVTGYLSEEEVLDTENPFVQLLSGVVWLIRNGSIYINESQATECDETQETGSFSKFVNVISARTAIGHDRKGQLVLFHADGQTEQRGINLWEMAEFLLKQDVVNAINLDGGGSATFVLNGTLASYPSDHCQDNMWRCPRQVSTVVCVHEPRCQPPDCHGHGTCVDGHCQCTGHFWRGPGCDELDCGPSNCSQHGLCTETGCRCDAGWTGSNCSEECPLGWHGPGCQRPCKCEHHCPCDPKTGNCSVSRVKQCLQPPEATLRAGELSFFTRTAWLALTLALAFLLLISTAANLSLLLSRAERNRRLHGDYAYHPLQEMNGEPLAAEKEQPGGAHNPFKD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus, Golgi stack membrane
Function
- Function:
- Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- Glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H(2)O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose.
- Cross Reference Drug Bank:
- DB00141
- Gene Ontology Go:
- Golgi cisterna membrane
integral component of membrane
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
carbohydrate metabolic process
cellular protein modification process
lysosome organization
protein glycosylation
protein targeting to lysosome - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular protein modification process
lysosome organization
protein glycosylation
protein targeting to lysosome - Gene Ontology Molecular Function:
- N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
- Gene Ontology Cellular Component:
- Golgi cisterna membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Golgi apparatus
Hydrolase
Membrane
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zymogen