Names & Taxonomy
- Uniprot ID:
- Q9UIG8
- Entry Name:
- SO3A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11)
- Gene Names:
- SLCO3A1 OATP3A1 OATPD SLC21A11
- Gene Names Primary:
- SLCO3A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 710
- Sequence:
- MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFFASTLTLDNLGRDPVPANQTHRTKFIYNLEDHEWCENMESVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=101 nM for PGE1 (isoform 1)
- Cross Reference Drug Bank:
- DB00770 DB00345 DB01053 DB00286 DB01160 DB00917 DB01088 DB00563
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
sodium-independent organic anion transmembrane transporter activity
prostaglandin transport
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Biological Process:
- prostaglandin transport
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Molecular Function:
- sodium-independent organic anion transmembrane transporter activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport