Names & Taxonomy

Uniprot ID:
Q9UIG8
Entry Name:
SO3A1_HUMAN
Status:
reviewed
Protein Names:
Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11)
Gene Names:
SLCO3A1 OATP3A1 OATPD SLC21A11
Gene Names Primary:
SLCO3A1
Organism:
Homo sapiens (Human)

Structure

Length:
710
Sequence:
MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFFASTLTLDNLGRDPVPANQTHRTKFIYNLEDHEWCENMESVL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=101 nM for PGE1 (isoform 1)
Cross Reference Drug Bank:
DB00770 DB00345 DB01053 DB00286 DB01160 DB00917 DB01088 DB00563
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
sodium-independent organic anion transmembrane transporter activity
prostaglandin transport
sodium-independent organic anion transport
transmembrane transport
Gene Ontology Biological Process:
prostaglandin transport
sodium-independent organic anion transport
transmembrane transport
Gene Ontology Molecular Function:
sodium-independent organic anion transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10873595 14702039 16572171 15489334 16971491 22814378