Names & Taxonomy
- Uniprot ID:
- Q9UI42
- Entry Name:
- CBPA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)
- Gene Names:
- CPA4 CPA3 UNQ694/PRO1339
- Gene Names Orf:
- UNQ694/PRO1339
- Gene Names Primary:
- CPA4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 421
- Sequence:
- MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Metalloprotease that could be involved in the histone hyperacetylation pathway.
- Catalytic Activity:
- Release of a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=55.6 uM for 3-(2-furyl)acryloyl-Phe-Phe
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by interaction with the metallocarboxypeptidase inhibitor (MCPI) from N.versicolor that binds to the catalytic zinc ion.
- Active Site:
- ACT_SITE 382 382 Proton donor/acceptor.
- Gene Ontology Go:
- extracellular space
metallocarboxypeptidase activity
zinc ion binding
histone acetylation - Gene Ontology Biological Process:
- histone acetylation
- Gene Ontology Molecular Function:
- metallocarboxypeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular space
- Keywords:
- 3D-structure
Alternative splicing
Carboxypeptidase
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen