Names & Taxonomy

Uniprot ID:
Q9UI42
Entry Name:
CBPA4_HUMAN
Status:
reviewed
Protein Names:
Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)
Gene Names:
CPA4 CPA3 UNQ694/PRO1339
Gene Names Orf:
UNQ694/PRO1339
Gene Names Primary:
CPA4
Organism:
Homo sapiens (Human)

Structure

Length:
421
Sequence:
MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Metalloprotease that could be involved in the histone hyperacetylation pathway.
Catalytic Activity:
Release of a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=55.6 uM for 3-(2-furyl)acryloyl-Phe-Phe
Enzyme Regulation:
ENZYME REGULATION: Inhibited by interaction with the metallocarboxypeptidase inhibitor (MCPI) from N.versicolor that binds to the catalytic zinc ion.
Active Site:
ACT_SITE 382 382 Proton donor/acceptor.
Gene Ontology Go:
extracellular space
metallocarboxypeptidase activity
zinc ion binding
histone acetylation
Gene Ontology Biological Process:
histone acetylation
Gene Ontology Molecular Function:
metallocarboxypeptidase activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular space
Keywords:
3D-structure
Alternative splicing
Carboxypeptidase
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen

Publication

PubMed ID:
10383164 12975309 14702039 12853948 15489334 12552318 20385563 16091843 15738388 22294694