Names & Taxonomy

Uniprot ID:
Q9UHW9
Entry Name:
S12A6_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)
Gene Names:
SLC12A6 KCC3
Gene Names Primary:
SLC12A6
Organism:
Homo sapiens (Human)

Structure

Length:
1150
Sequence:
MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Basolateral cell membrane

Function

Function:
Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.7 mM for extracellular Rb(+) (isoform 1)
Enzyme Regulation:
ENZYME REGULATION: Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3.
Cross Reference Drug Bank:
DB00761
Gene Ontology Go:
basolateral plasma membrane
integral component of membrane
integral component of plasma membrane
plasma membrane
potassium ion symporter activity
potassium ion transmembrane transporter activity
potassium:chloride symporter activity
protein kinase binding
rubidium ion transmembrane transporter activity
angiogenesis
cellular hypotonic response
cellular hypotonic salinity response
ion transport
potassium ion import
potassium ion transmembrane transport
rubidium ion transport
synaptic transmission
transmembrane transport
Gene Ontology Biological Process:
angiogenesis
cellular hypotonic response
cellular hypotonic salinity response
ion transport
potassium ion import
potassium ion transmembrane transport
rubidium ion transport
synaptic transmission
transmembrane transport
Gene Ontology Molecular Function:
potassium:chloride symporter activity
potassium ion symporter activity
potassium ion transmembrane transporter activity
protein kinase binding
rubidium ion transmembrane transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
integral component of membrane
integral component of plasma membrane
plasma membrane
Keywords:
Alternative promoter usage
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Neuropathy
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10600773 10187864 10347194 12368912 16048901 14702039 16572171 15489334 17974005 11551954 18669648 19690332 21613606 21406692