Names & Taxonomy
- Uniprot ID:
- Q9UHW9
- Entry Name:
- S12A6_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)
- Gene Names:
- SLC12A6 KCC3
- Gene Names Primary:
- SLC12A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1150
- Sequence:
- MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane
Function
- Function:
- Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.7 mM for extracellular Rb(+) (isoform 1)
- Enzyme Regulation:
- ENZYME REGULATION: Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3.
- Cross Reference Drug Bank:
- DB00761
- Gene Ontology Go:
- basolateral plasma membrane
integral component of membrane
integral component of plasma membrane
plasma membrane
potassium ion symporter activity
potassium ion transmembrane transporter activity
potassium:chloride symporter activity
protein kinase binding
rubidium ion transmembrane transporter activity
angiogenesis
cellular hypotonic response
cellular hypotonic salinity response
ion transport
potassium ion import
potassium ion transmembrane transport
rubidium ion transport
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- angiogenesis
cellular hypotonic response
cellular hypotonic salinity response
ion transport
potassium ion import
potassium ion transmembrane transport
rubidium ion transport
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- potassium:chloride symporter activity
potassium ion symporter activity
potassium ion transmembrane transporter activity
protein kinase binding
rubidium ion transmembrane transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative promoter usage
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Neuropathy
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport