Names & Taxonomy
- Uniprot ID:
- Q9UHQ9
- Entry Name:
- NB5R1_HUMAN
- Status:
- reviewed
- Protein Names:
- NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2)
- Gene Names:
- CYB5R1 NQO3A2 UNQ3049/PRO9865
- Gene Names Orf:
- UNQ3049/PRO9865
- Gene Names Primary:
- CYB5R1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 305
- Sequence:
- MGIQTSPVLLASLGVGLVTLLGLAVGSYLVRRSRRPQVTLLDPNEKYLLRLLDKTTVSHNTKRFRFALPTAHHTLGLPVGKHIYLSTRIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKVGDVVEFRGPSGLLTYTGKGHFNIQPNKKSPPEPRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQARYPNRFKLWFTLDHPPKDWAYSKGFVTADMIREHLPAPGDDVLVLLCGPPPMVQLACHPNLDKLGYSQKMRFTY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
- Catalytic Activity:
- NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB03147
- Gene Ontology Go:
- extracellular exosome
integral component of membrane
membrane
mitochondrion
cytochrome-b5 reductase activity, acting on NAD(P)H
positive regulation of protein targeting to mitochondrion
sterol biosynthetic process - Gene Ontology Biological Process:
- positive regulation of protein targeting to mitochondrion
sterol biosynthetic process - Gene Ontology Molecular Function:
- cytochrome-b5 reductase activity, acting on NAD(P)H
- Gene Ontology Cellular Component:
- extracellular exosome
integral component of membrane
membrane
mitochondrion - Keywords:
- Complete proteome
Direct protein sequencing
FAD
Flavoprotein
Lipid biosynthesis
Lipid metabolism
Membrane
NAD
Oxidoreductase
Polymorphism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transmembrane
Transmembrane helix - Interacts With:
- Q9UMX0; Q9UMX0-2