Names & Taxonomy
- Uniprot ID:
- Q9UHC6
- Entry Name:
- CNTP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Contactin-associated protein-like 2 (Cell recognition molecule Caspr2)
- Gene Names:
- CNTNAP2 CASPR2 KIAA0868
- Gene Names Primary:
- CNTNAP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1331
- Sequence:
- MQAAPRAGCGAALLLWIVSSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPDGSPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKEDFIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEWLI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (By similarity).
- Gene Ontology Go:
- axolemma
axon
cell surface
dendrite
early endosome
Golgi apparatus
integral component of membrane
juxtaparanode region of axon
membrane
neuronal cell body
perikaryon
voltage-gated potassium channel complex
enzyme binding
adult behavior
brain development
cell adhesion
cerebral cortex development
clustering of voltage-gated potassium channels
learning
limbic system development
neuron projection development
neuron recognition
protein localization to juxtaparanode region of axon
social behavior
striatum development
superior temporal gyrus development
thalamus development
transmission of nerve impulse
vocal learning
vocalization behavior - Gene Ontology Biological Process:
- adult behavior
brain development
cell adhesion
cerebral cortex development
clustering of voltage-gated potassium channels
learning
limbic system development
neuron projection development
neuron recognition
protein localization to juxtaparanode region of axon
social behavior
striatum development
superior temporal gyrus development
thalamus development
transmission of nerve impulse
vocalization behavior
vocal learning - Gene Ontology Molecular Function:
- enzyme binding
- Gene Ontology Cellular Component:
- axolemma
axon
cell surface
dendrite
early endosome
Golgi apparatus
integral component of membrane
juxtaparanode region of axon
membrane
neuronal cell body
perikaryon
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Autism
Autism spectrum disorder
Cell adhesion
Cell projection
Chromosomal rearrangement
Complete proteome
Disulfide bond
EGF-like domain
Epilepsy
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- A4D127