Names & Taxonomy
- Uniprot ID:
- Q9UHC3
- Entry Name:
- ASIC3_HUMAN
- Status:
- reviewed
- Protein Names:
- Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1)
- Gene Names:
- ASIC3 ACCN3 SLNAC1 TNAC1
- Gene Names Primary:
- ASIC3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 531
- Sequence:
- MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
plasma membrane
cation channel activity
enterobactin transporter activity
ligand-gated sodium channel activity
sodium channel activity
detection of chemical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception of pain
ion transmembrane transport
response to acidic pH
response to heat
sensory perception
sensory perception of sour taste
signal transduction
transmembrane transport
transport - Gene Ontology Biological Process:
- detection of chemical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception of pain
ion transmembrane transport
response to acidic pH
response to heat
sensory perception
sensory perception of sour taste
signal transduction
transmembrane transport
transport - Gene Ontology Molecular Function:
- cation channel activity
enterobactin transporter activity
ligand-gated sodium channel activity
sodium channel activity - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium channel
Sodium transport
Transmembrane
Transmembrane helix
Transport