Names & Taxonomy
- Uniprot ID:
- Q9UGN5
- Entry Name:
- PARP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2)
- Gene Names:
- PARP2 ADPRT2 ADPRTL2
- Gene Names Primary:
- PARP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 583
- Sequence:
- MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
- Catalytic Activity:
- NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
- Cross Reference Drug Bank:
- DB09074
- Gene Ontology Go:
- cytoplasm
nucleolus
nucleoplasm
nucleus
DNA binding
DNA ligase (ATP) activity
NAD+ ADP-ribosyltransferase activity
base-excision repair
DNA ligation involved in DNA repair
DNA repair
extrinsic apoptotic signaling pathway
lagging strand elongation
protein ADP-ribosylation - Gene Ontology Biological Process:
- base-excision repair
DNA ligation involved in DNA repair
DNA repair
extrinsic apoptotic signaling pathway
lagging strand elongation
protein ADP-ribosylation - Gene Ontology Molecular Function:
- DNA binding
DNA ligase (ATP) activity
NAD+ ADP-ribosyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
nucleolus
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
DNA-binding
Glycosyltransferase
NAD
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q00688; Q99469