Names & Taxonomy

Uniprot ID:
Q9UGJ0
Entry Name:
AAKG2_HUMAN
Status:
reviewed
Protein Names:
5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p)
Gene Names:
PRKAG2
Gene Names Primary:
PRKAG2
Organism:
Homo sapiens (Human)

Structure

Length:
569
Sequence:
MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPSSPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEAVEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE
Proteomes:
UP000005640

Function

Function:
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Cross Reference Drug Bank:
DB00945
Gene Ontology Go:
cytosol
extracellular space
nucleoplasm
nucleotide-activated protein kinase complex
ADP binding
AMP binding
AMP-activated protein kinase activity
ATP binding
cAMP-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase regulator activity
phosphorylase kinase regulator activity
protein kinase activator activity
protein kinase binding
activation of protein kinase activity
ATP biosynthetic process
carnitine shuttle
cell cycle arrest
cellular lipid metabolic process
energy reserve metabolic process
fatty acid biosynthetic process
gene expression
glycogen metabolic process
insulin receptor signaling pathway
intracellular signal transduction
macroautophagy
membrane organization
mitochondrion organization
negative regulation of protein kinase activity
negative regulation of protein serine/threonine kinase activity
organelle organization
positive regulation of peptidyl-threonine phosphorylation
positive regulation of protein kinase activity
regulation of fatty acid biosynthetic process
regulation of fatty acid metabolic process
regulation of fatty acid oxidation
regulation of glucose import
regulation of glycolytic process
small molecule metabolic process
sterol biosynthetic process
transcription initiation from RNA polymerase II promoter
Gene Ontology Biological Process:
activation of protein kinase activity
ATP biosynthetic process
carnitine shuttle
cell cycle arrest
cellular lipid metabolic process
energy reserve metabolic process
fatty acid biosynthetic process
gene expression
glycogen metabolic process
insulin receptor signaling pathway
intracellular signal transduction
macroautophagy
membrane organization
mitochondrion organization
negative regulation of protein kinase activity
negative regulation of protein serine/threonine kinase activity
organelle organization
positive regulation of peptidyl-threonine phosphorylation
positive regulation of protein kinase activity
regulation of fatty acid biosynthetic process
regulation of fatty acid metabolic process
regulation of fatty acid oxidation
regulation of glucose import
regulation of glycolytic process
small molecule metabolic process
sterol biosynthetic process
transcription initiation from RNA polymerase II promoter
Gene Ontology Molecular Function:
ADP binding
AMP-activated protein kinase activity
AMP binding
ATP binding
cAMP-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase regulator activity
phosphorylase kinase regulator activity
protein kinase activator activity
protein kinase binding
Gene Ontology Cellular Component:
cytosol
extracellular space
nucleoplasm
nucleotide-activated protein kinase complex
Keywords:
ATP-binding
Alternative splicing
CBS domain
Cardiomyopathy
Complete proteome
Disease mutation
Fatty acid biosynthesis
Fatty acid metabolism
Glycogen storage disease
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat

Publication

PubMed ID:
10698692 11112354 14702039 12853948 15489334 14722619 17255938 18691976 19413330 19369195 21460634 17307971 17712357 24275569 11748095 11371514 11407343 11827995 15877279