Names & Taxonomy

Uniprot ID:
Q9UGI6
Entry Name:
KCNN3_HUMAN
Status:
reviewed
Protein Names:
Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)
Gene Names:
KCNN3 K3
Gene Names Primary:
KCNN3
Organism:
Homo sapiens (Human)

Structure

Length:
736
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.
Intramembrane:
INTRAMEM 499 519 Pore-forming; Name=Segment H5.

Function

Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Cross Reference Drug Bank:
DB01110 DB00721
Gene Ontology Go:
integral component of membrane
neuronal cell body
plasma membrane
calmodulin binding
small conductance calcium-activated potassium channel activity
positive regulation of protein targeting to mitochondrion
potassium ion transmembrane transport
synaptic transmission
Gene Ontology Biological Process:
positive regulation of protein targeting to mitochondrion
potassium ion transmembrane transport
synaptic transmission
Gene Ontology Molecular Function:
calmodulin binding
small conductance calcium-activated potassium channel activity
Gene Ontology Cellular Component:
integral component of membrane
neuronal cell body
plasma membrane
Keywords:
Alternative splicing
Calmodulin-binding
Complete proteome
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9491810 11501944 12808432 16710414 15489334