Names & Taxonomy
- Uniprot ID:
- Q9UGI6
- Entry Name:
- KCNN3_HUMAN
- Status:
- reviewed
- Protein Names:
- Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)
- Gene Names:
- KCNN3 K3
- Gene Names Primary:
- KCNN3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 736
- Sequence:
- MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 499 519 Pore-forming; Name=Segment H5.
Function
- Function:
- Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
- Cross Reference Drug Bank:
- DB01110 DB00721
- Gene Ontology Go:
- integral component of membrane
neuronal cell body
plasma membrane
calmodulin binding
small conductance calcium-activated potassium channel activity
positive regulation of protein targeting to mitochondrion
potassium ion transmembrane transport
synaptic transmission - Gene Ontology Biological Process:
- positive regulation of protein targeting to mitochondrion
potassium ion transmembrane transport
synaptic transmission - Gene Ontology Molecular Function:
- calmodulin binding
small conductance calcium-activated potassium channel activity - Gene Ontology Cellular Component:
- integral component of membrane
neuronal cell body
plasma membrane - Keywords:
- Alternative splicing
Calmodulin-binding
Complete proteome
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport