Names & Taxonomy
- Uniprot ID:
- Q9UGH3
- Entry Name:
- S23A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)
- Gene Names:
- SLC23A2 KIAA0238 NBTL1 SLC23A1 SVCT2 YSPL2
- Gene Names Primary:
- SLC23A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 650
- Sequence:
- MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 289 302 Helical.
Function
- Function:
- Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
- Gene Ontology Go:
- apical plasma membrane
basal plasma membrane
basolateral plasma membrane
cytoplasm
integral component of membrane
integral component of plasma membrane
membrane
plasma membrane
L-ascorbate:sodium symporter activity
L-ascorbic acid transporter activity
nucleobase transmembrane transporter activity
sodium-dependent L-ascorbate transmembrane transporter activity
sodium-dependent multivitamin transmembrane transporter activity
carboxylic acid transmembrane transport
L-ascorbic acid metabolic process
L-ascorbic acid transport
molecular hydrogen transport
nucleobase transport
nucleobase-containing compound metabolic process
response to oxidative stress
small molecule metabolic process
transepithelial L-ascorbic acid transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- carboxylic acid transmembrane transport
L-ascorbic acid metabolic process
L-ascorbic acid transport
molecular hydrogen transport
nucleobase-containing compound metabolic process
nucleobase transport
response to oxidative stress
small molecule metabolic process
transepithelial L-ascorbic acid transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- L-ascorbate:sodium symporter activity
L-ascorbic acid transporter activity
nucleobase transmembrane transporter activity
sodium-dependent L-ascorbate transmembrane transporter activity
sodium-dependent multivitamin transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
basal plasma membrane
basolateral plasma membrane
cytoplasm
integral component of membrane
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport