Names & Taxonomy
- Uniprot ID:
- Q9UEF7
- Entry Name:
- KLOT_HUMAN
- Status:
- reviewed
- Protein Names:
- Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]
- Gene Names:
- KL
- Gene Names Primary:
- KL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1012
- Sequence:
- MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLERFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane
Function
- Function:
- May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
- Catalytic Activity:
- A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol.
- Gene Ontology Go:
- apical plasma membrane
extracellular exosome
extracellular region
extracellular space
integral component of membrane
integral component of plasma membrane
intracellular
plasma membrane
beta-glucosidase activity
beta-glucuronidase activity
fibroblast growth factor binding
signal transducer activity
vitamin D binding
activation of MAPKK activity
aging
axon guidance
calcium ion homeostasis
carbohydrate metabolic process
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of bone mineralization
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
aging
axon guidance
calcium ion homeostasis
carbohydrate metabolic process
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of bone mineralization
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- beta-glucosidase activity
beta-glucuronidase activity
fibroblast growth factor binding
signal transducer activity
vitamin D binding - Gene Ontology Cellular Component:
- apical plasma membrane
extracellular exosome
extracellular region
extracellular space
integral component of membrane
integral component of plasma membrane
intracellular
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Glycosidase
Hormone
Hydrolase
Membrane
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix
Vitamin D