Names & Taxonomy
- Uniprot ID:
- Q9UBT6
- Entry Name:
- POLK_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP)
- Gene Names:
- POLK DINB1
- Gene Names Primary:
- POLK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 870
- Sequence:
- MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNKLSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQVLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFSCSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALSNKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCPVCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTRTKRPGLMTKYSTSKKIKPNNPKHTLDIFFK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
- Catalytic Activity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Gene Ontology Go:
- intracellular membrane-bounded organelle
nucleoplasm
nucleus
damaged DNA binding
DNA-directed DNA polymerase activity
metal ion binding
DNA repair
DNA replication
error-prone translesion synthesis
global genome nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, DNA gap filling
nucleotide-excision repair, DNA incision
transcription-coupled nucleotide-excision repair
translesion synthesis - Gene Ontology Biological Process:
- DNA repair
DNA replication
error-prone translesion synthesis
global genome nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, DNA gap filling
nucleotide-excision repair, DNA incision
transcription-coupled nucleotide-excision repair
translesion synthesis - Gene Ontology Molecular Function:
- damaged DNA binding
DNA-directed DNA polymerase activity
metal ion binding - Gene Ontology Cellular Component:
- intracellular membrane-bounded organelle
nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
DNA damage
DNA repair
DNA replication
DNA synthesis
DNA-binding
DNA-directed DNA polymerase
Magnesium
Metal-binding
Mutator protein
Nucleotidyltransferase
Nucleus
Polymorphism
Reference proteome
Repeat
Schiff base
Transferase
Zinc
Zinc-finger