Names & Taxonomy
- Uniprot ID:
- Q9P2U8
- Entry Name:
- VGLU2_HUMAN
- Status:
- reviewed
- Protein Names:
- Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)
- Gene Names:
- SLC17A6 DNPI VGLUT2
- Gene Names Primary:
- SLC17A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 582
- Sequence:
- MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function
- Function:
- Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
- Gene Ontology Go:
- cell junction
integral component of membrane
neuron projection
synaptic vesicle membrane
L-glutamate transmembrane transporter activity
symporter activity
ion transport
L-glutamate transmembrane transport
neurotransmitter transport
sodium ion transport
transmembrane transport - Gene Ontology Biological Process:
- ion transport
L-glutamate transmembrane transport
neurotransmitter transport
sodium ion transport
transmembrane transport - Gene Ontology Molecular Function:
- L-glutamate transmembrane transporter activity
symporter activity - Gene Ontology Cellular Component:
- cell junction
integral component of membrane
neuron projection
synaptic vesicle membrane - Keywords:
- Cell junction
Complete proteome
Cytoplasmic vesicle
Glycoprotein
Ion transport
Membrane
Neurotransmitter transport
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Synapse
Synaptosome
Transmembrane
Transmembrane helix
Transport