Names & Taxonomy
- Uniprot ID:
- Q9P2U7
- Entry Name:
- VGLU1_HUMAN
- Status:
- reviewed
- Protein Names:
- Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)
- Gene Names:
- SLC17A7 BNPI VGLUT1
- Gene Names Primary:
- SLC17A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 560
- Sequence:
- MEFRQEEFRKLAGRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAEPPGAPPAPPPSYGATHSTFQPPRPPPPVRDY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function
- Function:
- Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
- Gene Ontology Go:
- cell junction
cerebellar mossy fiber
clathrin-sculpted glutamate transport vesicle membrane
excitatory synapse
integral component of membrane
plasma membrane
postsynapse
presynaptic active zone
synaptic vesicle membrane
extracellular-glutamate-gated chloride channel activity
inorganic phosphate transmembrane transporter activity
L-glutamate transmembrane transporter activity
sodium-dependent phosphate transmembrane transporter activity
sodium:inorganic phosphate symporter activity
brain development
excitatory postsynaptic potential
glutamate secretion
ion transport
L-glutamate import
L-glutamate transmembrane transport
long-term memory
neural retina development
neurotransmitter secretion
phosphate ion transmembrane transport
phosphate ion transport
sequestering of neurotransmitter
sodium ion transmembrane transport
synaptic transmission
synaptic transmission, glutamatergic
synaptic vesicle lumen acidification
transmembrane transport - Gene Ontology Biological Process:
- brain development
excitatory postsynaptic potential
glutamate secretion
ion transport
L-glutamate import
L-glutamate transmembrane transport
long-term memory
neural retina development
neurotransmitter secretion
phosphate ion transmembrane transport
phosphate ion transport
sequestering of neurotransmitter
sodium ion transmembrane transport
synaptic transmission
synaptic transmission, glutamatergic
synaptic vesicle lumen acidification
transmembrane transport - Gene Ontology Molecular Function:
- extracellular-glutamate-gated chloride channel activity
inorganic phosphate transmembrane transporter activity
L-glutamate transmembrane transporter activity
sodium:inorganic phosphate symporter activity
sodium-dependent phosphate transmembrane transporter activity - Gene Ontology Cellular Component:
- cell junction
cerebellar mossy fiber
clathrin-sculpted glutamate transport vesicle membrane
excitatory synapse
integral component of membrane
plasma membrane
postsynapse
presynaptic active zone
synaptic vesicle membrane - Keywords:
- Alternative splicing
Cell junction
Complete proteome
Cytoplasmic vesicle
Ion transport
Membrane
Neurotransmitter transport
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Synapse
Synaptosome
Transmembrane
Transmembrane helix
Transport