Names & Taxonomy
- Uniprot ID:
- Q9P2S2
- Entry Name:
- NRX2A_HUMAN
- Status:
- reviewed
- Protein Names:
- Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha)
- Gene Names:
- NRXN2 KIAA0921
- Gene Names Primary:
- NRXN2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1712
- Sequence:
- MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
- Gene Ontology Go:
- integral component of membrane
presynapse
protein complex
calcium channel regulator activity
cell adhesion molecule binding
metal ion binding
neuroligin family protein binding
transmembrane signaling receptor activity
adult behavior
gephyrin clustering involved in postsynaptic density assembly
neuroligin clustering involved in postsynaptic membrane assembly
neuron cell-cell adhesion
neurotransmitter secretion
postsynaptic density protein 95 clustering
postsynaptic membrane assembly
signal transduction
social behavior
synapse assembly
synaptic transmission
vocal learning
vocalization behavior - Gene Ontology Biological Process:
- adult behavior
gephyrin clustering involved in postsynaptic density assembly
neuroligin clustering involved in postsynaptic membrane assembly
neuron cell-cell adhesion
neurotransmitter secretion
postsynaptic density protein 95 clustering
postsynaptic membrane assembly
signal transduction
social behavior
synapse assembly
synaptic transmission
vocalization behavior
vocal learning - Gene Ontology Molecular Function:
- calcium channel regulator activity
cell adhesion molecule binding
metal ion binding
neuroligin family protein binding
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
presynapse
protein complex - Keywords:
- Alternative promoter usage
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix