Names & Taxonomy
- Uniprot ID:
- Q9P2K9
- Entry Name:
- DISP3_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein dispatched homolog 3 (Patched domain-containing protein 2)
- Gene Names:
- DISP3 KIAA1337 PTCHD2
- Gene Names Primary:
- DISP3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1392
- Sequence:
- MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGFWSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHAAVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHWVLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPSRKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSSSPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGVNRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQSGYKIPLPAGASL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity).
- Gene Ontology Go:
- cytoplasm
cytoplasmic vesicle
endoplasmic reticulum
integral component of membrane
nuclear membrane
hedgehog receptor activity
cholesterol homeostasis
cholesterol metabolic process
negative regulation of neuron differentiation
positive regulation of lipid metabolic process
positive regulation of neural precursor cell proliferation
regulation of lipid transport
smoothened signaling pathway - Gene Ontology Biological Process:
- cholesterol homeostasis
cholesterol metabolic process
negative regulation of neuron differentiation
positive regulation of lipid metabolic process
positive regulation of neural precursor cell proliferation
regulation of lipid transport
smoothened signaling pathway - Gene Ontology Molecular Function:
- hedgehog receptor activity
- Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic vesicle
endoplasmic reticulum
integral component of membrane
nuclear membrane - Keywords:
- Alternative splicing
Cholesterol metabolism
Complete proteome
Cytoplasmic vesicle
Differentiation
Endoplasmic reticulum
Glycoprotein
Lipid metabolism
Membrane
Nucleus
Polymorphism
Reference proteome
Steroid metabolism
Sterol metabolism
Transmembrane
Transmembrane helix