Names & Taxonomy
- Uniprot ID:
- Q9NZL9
- Entry Name:
- MAT2B_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase)
- Gene Names:
- MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995
- Gene Names Orf:
- MSTP045 Nbla02999 UNQ2435/PRO4995
- Gene Names Primary:
- MAT2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 334
- Sequence:
- MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKLETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
- Proteomes:
- UP000005640
Function
- Function:
- Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.
- Pathway:
- Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
- Cross Reference Drug Bank:
- DB00134
- Gene Ontology Go:
- cytosol
extracellular exosome
intracellular
methionine adenosyltransferase complex
mitochondrion
nucleus
enzyme binding
methionine adenosyltransferase regulator activity
methylation
one-carbon metabolic process
regulation of catalytic activity
S-adenosylmethionine biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- methylation
one-carbon metabolic process
regulation of catalytic activity
S-adenosylmethionine biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- enzyme binding
methionine adenosyltransferase regulator activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
intracellular
methionine adenosyltransferase complex
mitochondrion
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
One-carbon metabolism
Polymorphism
Reference proteome - Interacts With:
- Q8IYQ9; O00629; P31153; P14373