Names & Taxonomy
- Uniprot ID:
- Q9NY72
- Entry Name:
- SCN3B_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium channel subunit beta-3
- Gene Names:
- SCN3B KIAA1158
- Gene Names Primary:
- SCN3B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 215
- Sequence:
- MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).
- Cross Reference Drug Bank:
- DB00313 DB00909
- Gene Ontology Go:
- integral component of membrane
plasma membrane
voltage-gated sodium channel complex
Z disc
ion channel binding
sodium channel regulator activity
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
atrial cardiac muscle cell action potential
cardiac muscle cell action potential involved in contraction
cardiac muscle contraction
membrane depolarization
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
nervous system development
positive regulation of heart rate
positive regulation of sodium ion transport
protein localization to plasma membrane
regulation of atrial cardiac muscle cell membrane depolarization
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
regulation of ventricular cardiac muscle cell membrane depolarization
SA node cell action potential
sensory perception of pain
sodium ion transmembrane transport
sodium ion transport
ventricular cardiac muscle cell action potential - Gene Ontology Biological Process:
- atrial cardiac muscle cell action potential
cardiac muscle cell action potential involved in contraction
cardiac muscle contraction
membrane depolarization
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
nervous system development
positive regulation of heart rate
positive regulation of sodium ion transport
protein localization to plasma membrane
regulation of atrial cardiac muscle cell membrane depolarization
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
regulation of ventricular cardiac muscle cell membrane depolarization
SA node cell action potential
sensory perception of pain
sodium ion transmembrane transport
sodium ion transport
ventricular cardiac muscle cell action potential - Gene Ontology Molecular Function:
- ion channel binding
sodium channel regulator activity
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane
voltage-gated sodium channel complex
Z disc - Keywords:
- 3D-structure
Atrial fibrillation
Brugada syndrome
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Ion channel
Ion transport
Membrane
Polymorphism
Reference proteome
Signal
Sodium
Sodium channel
Sodium transport
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel