Names & Taxonomy
- Uniprot ID:
- Q9NXG6
- Entry Name:
- P4HTM_HUMAN
- Status:
- reviewed
- Protein Names:
- Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4)
- Gene Names:
- P4HTM PH4
- Gene Names Primary:
- P4HTM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 502
- Sequence:
- MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWALDRAYRDARVEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
- Catalytic Activity:
- An HIF alpha chain L-proline + 2-oxoglutarate + O(2) = An HIF alpha chain trans-4-hydroxy-L-proline + succinate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Cross Reference Drug Bank:
- DB00126
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
iron ion binding
L-ascorbic acid binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
regulation of erythrocyte differentiation - Gene Ontology Biological Process:
- regulation of erythrocyte differentiation
- Gene Ontology Molecular Function:
- iron ion binding
L-ascorbic acid binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Calcium
Complete proteome
Dioxygenase
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Oxidoreductase
Reference proteome
Repeat
Signal-anchor
Transmembrane
Transmembrane helix
Vitamin C