Names & Taxonomy
- Uniprot ID:
- Q9NWZ5
- Entry Name:
- UCKL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Uridine-cytidine kinase-like 1 (EC 2.7.1.48)
- Gene Names:
- UCKL1 URKL1 F538
- Gene Names Orf:
- F538
- Gene Names Primary:
- UCKL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 548
- Sequence:
- MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRSNAESLDRLLPPVGTGRSPRKRTTSQCKSEPPLLRTSKRTIYTAGRPPWYNEHGTQSKEAFAIGLGGGSASGKTTVARMIIEALDVPWVVLLSMDSFYKVLTEQQQEQAAHNNFNFDHPDAFDFDLIISTLKKLKQGKSVKVPIYDFTTHSRKKDWKTLYGANVIIFEGIMAFADKTLLELLDMKIFVDTDSDIRLVRRLRRDISERGRDIEGVIKQYNKFVKPSFDQYIQPTMRLADIVVPRGSGNTVAIDLIVQHVHSQLEERELSVRAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTAVDKRVNDLFRIIPGIGNFGDRYFGTDAVPDGSDEEEVAYTG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- May contribute to UTP accumulation needed for blast transformation and proliferation.
- Pathway:
- Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
- Catalytic Activity:
- ATP + uridine = ADP + UMP.; ATP + cytidine = ADP + CMP.
- Gene Ontology Go:
- cytosol
nucleus
ATP binding
uridine kinase activity
CTP salvage
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
UMP salvage
viral process - Gene Ontology Biological Process:
- CTP salvage
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
UMP salvage
viral process - Gene Ontology Molecular Function:
- ATP binding
uridine kinase activity - Gene Ontology Cellular Component:
- cytosol
nucleus - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Host-virus interaction
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation - Interacts With:
- P12977; Q6ZMZ0