Names & Taxonomy
- Uniprot ID:
- Q9NWM0
- Entry Name:
- SMOX_HUMAN
- Status:
- reviewed
- Protein Names:
- Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)
- Gene Names:
- SMOX C20orf16 SMO UNQ3039/PRO9854
- Gene Names Orf:
- UNQ3039/PRO9854
- Gene Names Primary:
- SMOX
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 555
- Sequence:
- MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cytoplasm. Nucleus.; Isoform 4: Cytoplasm. Nucleus.; Isoform 6: Cytoplasm. Nucleus.
Function
- Function:
- Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
- Pathway:
- Amine and polyamine degradation; spermine degradation.
- Catalytic Activity:
- Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2).
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=0.6 uM for spermine (isoform 1)
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1 uM.
- Cross Reference Drug Bank:
- DB00127
- Gene Ontology Go:
- cytoplasm
cytosol
nucleus
N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
norspermine:oxygen oxidoreductase activity
polyamine oxidase activity
spermine:oxygen oxidoreductase (spermidine-forming) activity
cellular nitrogen compound metabolic process
oxidation-reduction process
polyamine biosynthetic process
polyamine catabolic process
polyamine metabolic process
small molecule metabolic process
spermine catabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
oxidation-reduction process
polyamine biosynthetic process
polyamine catabolic process
polyamine metabolic process
small molecule metabolic process
spermine catabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
norspermine:oxygen oxidoreductase activity
polyamine oxidase activity
spermine:oxygen oxidoreductase (spermidine-forming) activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleus - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
FAD
Flavoprotein
Nucleus
Oxidoreductase
Polymorphism
Reference proteome