Names & Taxonomy

Uniprot ID:
Q9NVS9
Entry Name:
PNPO_HUMAN
Status:
reviewed
Protein Names:
Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase)
Gene Names:
PNPO
Gene Names Primary:
PNPO
Organism:
Homo sapiens (Human)

Structure

Length:
261
Sequence:
MTCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDREAFEETHLTSLDPVKQFAAWFEEAVQCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNFESRKGKELDSNPFASLVFYWEPLNRQVRVEGPVKKLPEEEAECYFHSRPKSSQIGAVVSHQSSVIPDREYLRKKNEELEQLYQDQEVPKPKSWGGYVLYPQVMEFWQGQTNRLHDRIVFRRGLPTGDSPLGPMTHRGEEDWLYERLAP
Proteomes:
UP000005640

Function

Function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Pathway:
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.; Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.
Catalytic Activity:
Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2).; Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2).
Cofactor:
COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210;
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
nucleoplasm
FMN binding
pyridoxamine-phosphate oxidase activity
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
pyridoxal phosphate biosynthetic process
pyridoxine biosynthetic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenophagy
Gene Ontology Biological Process:
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
pyridoxal phosphate biosynthetic process
pyridoxine biosynthetic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenophagy
Gene Ontology Molecular Function:
FMN binding
pyridoxamine-phosphate oxidase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
nucleoplasm
Keywords:
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Epilepsy
FMN
Flavoprotein
Oxidoreductase
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Pyridoxine biosynthesis
Reference proteome

Publication

PubMed ID:
14702039 16625196 15489334 21269460 24275569 12824491 15772097