Names & Taxonomy
- Uniprot ID:
- Q9NVS9
- Entry Name:
- PNPO_HUMAN
- Status:
- reviewed
- Protein Names:
- Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase)
- Gene Names:
- PNPO
- Gene Names Primary:
- PNPO
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MTCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDREAFEETHLTSLDPVKQFAAWFEEAVQCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNFESRKGKELDSNPFASLVFYWEPLNRQVRVEGPVKKLPEEEAECYFHSRPKSSQIGAVVSHQSSVIPDREYLRKKNEELEQLYQDQEVPKPKSWGGYVLYPQVMEFWQGQTNRLHDRIVFRRGLPTGDSPLGPMTHRGEEDWLYERLAP
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
- Pathway:
- Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.; Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.
- Catalytic Activity:
- Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2).; Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2).
- Cofactor:
- COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210;
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
FMN binding
pyridoxamine-phosphate oxidase activity
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
pyridoxal phosphate biosynthetic process
pyridoxine biosynthetic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenophagy - Gene Ontology Biological Process:
- mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
pyridoxal phosphate biosynthetic process
pyridoxine biosynthetic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenophagy - Gene Ontology Molecular Function:
- FMN binding
pyridoxamine-phosphate oxidase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Epilepsy
FMN
Flavoprotein
Oxidoreductase
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Pyridoxine biosynthesis
Reference proteome