Names & Taxonomy

Uniprot ID:
Q9NSE4
Entry Name:
SYIM_HUMAN
Status:
reviewed
Protein Names:
Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)
Gene Names:
IARS2
Gene Names Primary:
IARS2
Organism:
Homo sapiens (Human)

Structure

Length:
1012
Sequence:
MRWGLRPRGPGAAALATARSLWGTPRLPCSPGWQGATKRLLVRSVSGASNHQPNSNSGRYRDTVLLPQTSFPMKLLGRQQPDTELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMNGSKIHFVPGWDCHGLPIEIKVLSELGREAQNLSAMEIRKKARSFAKAAIEKQKSAFIRWGIMADWNNCYYTFDGKYEAKQLRTFYQMYDKGLVYRSYKPVFWSPSSRTALAEAELEYNPEHVSRSIYVKFPLLKPSPKLASLIDGSSPVSILVWTTQPWTIPANEAVCYMPESKYAVVKCSKSGDLYVLAADKVASVASTLETTFETISTLSGVDLENGTCSHPLIPDKASPLLPANHVTMAKGTGLVHTAPAHGMEDYGVASQHNLPMDCLVDEDGVFTDVAGPELQNKAVLEEGTDVVIKMLQTAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFINITDIKTAAKELLKKVKFIPGSALNGMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIVKLVEQHGSDIWWTLPPEQLLPKEVLSEVGGPDALEYVPGQDILDIWFDSGTSWSYVLPGPDQRADLYLEGKDQLGGWFQSSLLTSVAARKRAPYKTVIVHGFTLGEKGEKMSKSLGNVIHPDVVVNGGQDQSKEPPYGADVLRWWVADSNVFTEVAIGPSVLNAARDDISKLRNTLRFLLGNVADFNPETDSIPVNDMYVIDQYMLHLLQDLANKITELYKQYDFGKVVRLLRTFYTRELSNFYFSIIKDRLYCEKENDPKRRSCQTALVEILDVIVRSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWISTSSIWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYKVITVIEPGLLFEIIEMLQSEETSSTSQLNELMMASESTLLAQEPREMTADVIELKGKFLINLEGGDIREESSYKVIVMPTTKEKCPRCWKYTAESSDTLCPRCAEVVSGK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix

Function

Catalytic Activity:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).
Cross Reference Drug Bank:
DB00167
Gene Ontology Go:
cytoplasm
mitochondrial matrix
mitochondrion
aminoacyl-tRNA editing activity
ATP binding
isoleucine-tRNA ligase activity
gene expression
isoleucyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Biological Process:
gene expression
isoleucyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Molecular Function:
aminoacyl-tRNA editing activity
ATP binding
isoleucine-tRNA ligase activity
Gene Ontology Cellular Component:
cytoplasm
mitochondrial matrix
mitochondrion
Keywords:
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Cataract
Complete proteome
Deafness
Disease mutation
Ligase
Mitochondrion
Neuropathy
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide

Publication

PubMed ID:
16710414 15489334 14702039 19608861 21269460 25130867 24275569 25944712