Names & Taxonomy
- Uniprot ID:
- Q9NSE4
- Entry Name:
- SYIM_HUMAN
- Status:
- reviewed
- Protein Names:
- Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)
- Gene Names:
- IARS2
- Gene Names Primary:
- IARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1012
- Sequence:
- MRWGLRPRGPGAAALATARSLWGTPRLPCSPGWQGATKRLLVRSVSGASNHQPNSNSGRYRDTVLLPQTSFPMKLLGRQQPDTELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMNGSKIHFVPGWDCHGLPIEIKVLSELGREAQNLSAMEIRKKARSFAKAAIEKQKSAFIRWGIMADWNNCYYTFDGKYEAKQLRTFYQMYDKGLVYRSYKPVFWSPSSRTALAEAELEYNPEHVSRSIYVKFPLLKPSPKLASLIDGSSPVSILVWTTQPWTIPANEAVCYMPESKYAVVKCSKSGDLYVLAADKVASVASTLETTFETISTLSGVDLENGTCSHPLIPDKASPLLPANHVTMAKGTGLVHTAPAHGMEDYGVASQHNLPMDCLVDEDGVFTDVAGPELQNKAVLEEGTDVVIKMLQTAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFINITDIKTAAKELLKKVKFIPGSALNGMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIVKLVEQHGSDIWWTLPPEQLLPKEVLSEVGGPDALEYVPGQDILDIWFDSGTSWSYVLPGPDQRADLYLEGKDQLGGWFQSSLLTSVAARKRAPYKTVIVHGFTLGEKGEKMSKSLGNVIHPDVVVNGGQDQSKEPPYGADVLRWWVADSNVFTEVAIGPSVLNAARDDISKLRNTLRFLLGNVADFNPETDSIPVNDMYVIDQYMLHLLQDLANKITELYKQYDFGKVVRLLRTFYTRELSNFYFSIIKDRLYCEKENDPKRRSCQTALVEILDVIVRSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWISTSSIWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYKVITVIEPGLLFEIIEMLQSEETSSTSQLNELMMASESTLLAQEPREMTADVIELKGKFLINLEGGDIREESSYKVIVMPTTKEKCPRCWKYTAESSDTLCPRCAEVVSGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Catalytic Activity:
- ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).
- Cross Reference Drug Bank:
- DB00167
- Gene Ontology Go:
- cytoplasm
mitochondrial matrix
mitochondrion
aminoacyl-tRNA editing activity
ATP binding
isoleucine-tRNA ligase activity
gene expression
isoleucyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
isoleucyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- aminoacyl-tRNA editing activity
ATP binding
isoleucine-tRNA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
mitochondrial matrix
mitochondrion - Keywords:
- ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Cataract
Complete proteome
Deafness
Disease mutation
Ligase
Mitochondrion
Neuropathy
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide