Names & Taxonomy
- Uniprot ID:
- Q9NSD9
- Entry Name:
- SYFB_HUMAN
- Status:
- reviewed
- Protein Names:
- Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)
- Gene Names:
- FARSB FARSLB FRSB HSPC173
- Gene Names Orf:
- HSPC173
- Gene Names Primary:
- FARSB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 589
- Sequence:
- MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQGNVKAAGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKAPVYKRVMPDGKIQKLIITEETAKIRPFAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTACELMNIYKTDNHLKHYLHIIENKPLYPVIYDSNGVVLSMPPIINGDHSRITVNTRNIFIECTGTDFTKAKIVLDIIVTMFSEYCENQFTVEAAEVVFPNGKSHTFPELAYRKEMVRADLINKKVGIRETPENLAKLLTRMYLKSEVIGDGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELLRHDMAAAGFTEALTFALCSQEDIADKLGVDISATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMPLPLKLFEISDIVIKDSNTDVGAKNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGEDKGGYVIKASEGPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMPCSSLEINVGPFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Catalytic Activity:
- ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
- Cross Reference Drug Bank:
- DB00120
- Gene Ontology Go:
- cytoplasm
cytosol
membrane
phenylalanine-tRNA ligase complex
ATP binding
magnesium ion binding
phenylalanine-tRNA ligase activity
RNA binding
gene expression
phenylalanyl-tRNA aminoacylation
translation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
phenylalanyl-tRNA aminoacylation
translation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
magnesium ion binding
phenylalanine-tRNA ligase activity
RNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
membrane
phenylalanine-tRNA ligase complex - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Ligase
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome