Names & Taxonomy

Uniprot ID:
Q9NRX5
Entry Name:
SERC1_HUMAN
Status:
reviewed
Protein Names:
Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2)
Gene Names:
SERINC1 KIAA1253 TDE1L TDE2 UNQ396/PRO732
Gene Names Orf:
UNQ396/PRO732
Gene Names Primary:
SERINC1
Organism:
Homo sapiens (Human)

Structure

Length:
453
Sequence:
MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAVHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLCVGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTTSTVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARSDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
Gene Ontology Go:
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
plasma membrane
L-serine transmembrane transporter activity
L-serine transport
phosphatidylserine metabolic process
phospholipid biosynthetic process
positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
positive regulation of serine C-palmitoyltransferase activity
sphingolipid metabolic process
Gene Ontology Biological Process:
L-serine transport
phosphatidylserine metabolic process
phospholipid biosynthetic process
positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
positive regulation of serine C-palmitoyltransferase activity
sphingolipid metabolic process
Gene Ontology Molecular Function:
L-serine transmembrane transporter activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
plasma membrane
Keywords:
Complete proteome
Endoplasmic reticulum
Glycoprotein
Lipid biosynthesis
Lipid metabolism
Lipoprotein
Membrane
Myristate
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Interacts With:
Q06710

Publication

PubMed ID:
10574462 17974005 10931946 12975309 14702039 14574404 15489334 17081983 18669648 19159218 19690332 20213681 24275569