Names & Taxonomy
- Uniprot ID:
- Q9NRF9
- Entry Name:
- DPOE3_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)
- Gene Names:
- POLE3 CHRAC17
- Gene Names Primary:
- POLE3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 147
- Sequence:
- MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQDKSRDEDNDEDEERLEEEEQNEEEEVDN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.
- Catalytic Activity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- Cross Reference Drug Bank:
- DB00242
- Gene Ontology Go:
- Ada2/Gcn5/Ada3 transcription activator complex
epsilon DNA polymerase complex
nucleus
DNA binding
DNA-directed DNA polymerase activity
DNA biosynthetic process
DNA replication
histone H3 acetylation - Gene Ontology Biological Process:
- DNA biosynthetic process
DNA replication
histone H3 acetylation - Gene Ontology Molecular Function:
- DNA binding
DNA-directed DNA polymerase activity - Gene Ontology Cellular Component:
- Ada2/Gcn5/Ada3 transcription activator complex
epsilon DNA polymerase complex
nucleus - Keywords:
- Acetylation
Coiled coil
Complete proteome
DNA-binding
DNA-directed DNA polymerase
Direct protein sequencing
Nucleotidyltransferase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q9NRG0; Q658N3; Q14919; Q9Q2G4; Q9NR33