Names & Taxonomy
- Uniprot ID:
- Q9NRD9
- Entry Name:
- DUOX1_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1)
- Gene Names:
- DUOX1 DUOX LNOX1 THOX1
- Gene Names Primary:
- DUOX1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1551
- Sequence:
- MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
- Pathway:
- Hormone biosynthesis; thyroid hormone biosynthesis.
- Catalytic Activity:
- NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
- Enzyme Regulation:
- ENZYME REGULATION: The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.
- Gene Ontology Go:
- apical plasma membrane
integral component of membrane
plasma membrane
calcium ion binding
heme binding
NAD(P)H oxidase activity
NADP binding
peroxidase activity
cellular nitrogen compound metabolic process
cuticle development
cytokine-mediated signaling pathway
hormone biosynthetic process
hydrogen peroxide biosynthetic process
hydrogen peroxide catabolic process
oxidation-reduction process
response to cAMP
response to oxidative stress
small molecule metabolic process
superoxide anion generation
thyroid hormone generation - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cuticle development
cytokine-mediated signaling pathway
hormone biosynthetic process
hydrogen peroxide biosynthetic process
hydrogen peroxide catabolic process
oxidation-reduction process
response to cAMP
response to oxidative stress
small molecule metabolic process
superoxide anion generation
thyroid hormone generation - Gene Ontology Molecular Function:
- calcium ion binding
heme binding
NAD(P)H oxidase activity
NADP binding
peroxidase activity - Gene Ontology Cellular Component:
- apical plasma membrane
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Calcium
Cell membrane
Complete proteome
FAD
Flavoprotein
Glycoprotein
Hydrogen peroxide
Membrane
Metal-binding
NADP
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane
Transmembrane helix