Names & Taxonomy

Uniprot ID:
Q9NRD9
Entry Name:
DUOX1_HUMAN
Status:
reviewed
Protein Names:
Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1)
Gene Names:
DUOX1 DUOX LNOX1 THOX1
Gene Names Primary:
DUOX1
Organism:
Homo sapiens (Human)

Structure

Length:
1551
Sequence:
MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane

Function

Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Pathway:
Hormone biosynthesis; thyroid hormone biosynthesis.
Catalytic Activity:
NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
Enzyme Regulation:
ENZYME REGULATION: The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.
Gene Ontology Go:
apical plasma membrane
integral component of membrane
plasma membrane
calcium ion binding
heme binding
NAD(P)H oxidase activity
NADP binding
peroxidase activity
cellular nitrogen compound metabolic process
cuticle development
cytokine-mediated signaling pathway
hormone biosynthetic process
hydrogen peroxide biosynthetic process
hydrogen peroxide catabolic process
oxidation-reduction process
response to cAMP
response to oxidative stress
small molecule metabolic process
superoxide anion generation
thyroid hormone generation
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
cuticle development
cytokine-mediated signaling pathway
hormone biosynthetic process
hydrogen peroxide biosynthetic process
hydrogen peroxide catabolic process
oxidation-reduction process
response to cAMP
response to oxidative stress
small molecule metabolic process
superoxide anion generation
thyroid hormone generation
Gene Ontology Molecular Function:
calcium ion binding
heme binding
NAD(P)H oxidase activity
NADP binding
peroxidase activity
Gene Ontology Cellular Component:
apical plasma membrane
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Calcium
Cell membrane
Complete proteome
FAD
Flavoprotein
Glycoprotein
Hydrogen peroxide
Membrane
Metal-binding
NADP
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10806195 11514595 14702039 16572171 15489334 11822874 12824283 15210697 16111680 15561711 15972824