Names & Taxonomy

Uniprot ID:
Q9NRD8
Entry Name:
DUOX2_HUMAN
Status:
reviewed
Protein Names:
Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138-tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase)
Gene Names:
DUOX2 LNOX2 THOX2
Gene Names Primary:
DUOX2
Organism:
Homo sapiens (Human)

Structure

Length:
1548
Sequence:
MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane

Function

Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Pathway:
Hormone biosynthesis; thyroid hormone biosynthesis.
Catalytic Activity:
NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
Enzyme Regulation:
ENZYME REGULATION: Peroxidase activity is inhibited by aminobenzohydrazide (By similarity). The NADPH oxidase activity is calcium-dependent.
Gene Ontology Go:
apical plasma membrane
cell junction
extracellular exosome
integral component of membrane
plasma membrane
calcium ion binding
heme binding
NAD(P)H oxidase activity
peroxidase activity
adenohypophysis morphogenesis
bone mineralization
cellular nitrogen compound metabolic process
cuticle development
cytokine-mediated signaling pathway
fertilization
hormone biosynthetic process
hydrogen peroxide biosynthetic process
hydrogen peroxide catabolic process
inner ear development
multicellular organism growth
oxidation-reduction process
response to cAMP
response to oxidative stress
response to virus
small molecule metabolic process
thyroid gland development
thyroid hormone generation
Gene Ontology Biological Process:
adenohypophysis morphogenesis
bone mineralization
cellular nitrogen compound metabolic process
cuticle development
cytokine-mediated signaling pathway
fertilization
hormone biosynthetic process
hydrogen peroxide biosynthetic process
hydrogen peroxide catabolic process
inner ear development
multicellular organism growth
oxidation-reduction process
response to cAMP
response to oxidative stress
response to virus
small molecule metabolic process
thyroid gland development
thyroid hormone generation
Gene Ontology Molecular Function:
calcium ion binding
heme binding
NAD(P)H oxidase activity
peroxidase activity
Gene Ontology Cellular Component:
apical plasma membrane
cell junction
extracellular exosome
integral component of membrane
plasma membrane
Keywords:
Calcium
Cell junction
Cell membrane
Complete proteome
Congenital hypothyroidism
Disease mutation
FAD
Flavoprotein
Glycoprotein
Hydrogen peroxide
Membrane
Metal-binding
NADP
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10806195 11514595 16572171 10601291 20187165 11822874 12110737 12824283 15210697 15591162 15561711 15972824 16134168 16322276 26301257