Names & Taxonomy
- Uniprot ID:
- Q9NR97
- Entry Name:
- TLR8_HUMAN
- Status:
- reviewed
- Protein Names:
- Toll-like receptor 8 (CD antigen CD288)
- Gene Names:
- TLR8 UNQ249/PRO286
- Gene Names Orf:
- UNQ249/PRO286
- Gene Names Primary:
- TLR8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1041
- Sequence:
- MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
- Cross Reference Drug Bank:
- DB00724
- Gene Ontology Go:
- endolysosome membrane
endoplasmic reticulum membrane
endosome membrane
Golgi membrane
integral component of membrane
DNA binding
double-stranded RNA binding
drug binding
receptor activity
RNA binding
single-stranded RNA binding
cellular response to mechanical stimulus
defense response to virus
I-kappaB kinase/NF-kappaB signaling
immunoglobulin mediated immune response
inflammatory response
innate immune response
microglial cell activation
MyD88-dependent toll-like receptor signaling pathway
positive regulation of innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-8 biosynthetic process
regulation of cytokine secretion
regulation of protein phosphorylation
response to virus
toll-like receptor 8 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Biological Process:
- cellular response to mechanical stimulus
defense response to virus
I-kappaB kinase/NF-kappaB signaling
immunoglobulin mediated immune response
inflammatory response
innate immune response
microglial cell activation
MyD88-dependent toll-like receptor signaling pathway
positive regulation of innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-8 biosynthetic process
regulation of cytokine secretion
regulation of protein phosphorylation
response to virus
toll-like receptor 8 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- DNA binding
double-stranded RNA binding
drug binding
receptor activity
RNA binding
single-stranded RNA binding - Gene Ontology Cellular Component:
- endolysosome membrane
endoplasmic reticulum membrane
endosome membrane
Golgi membrane
integral component of membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Leucine-rich repeat
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix