Names & Taxonomy

Uniprot ID:
Q9NR97
Entry Name:
TLR8_HUMAN
Status:
reviewed
Protein Names:
Toll-like receptor 8 (CD antigen CD288)
Gene Names:
TLR8 UNQ249/PRO286
Gene Names Orf:
UNQ249/PRO286
Gene Names Primary:
TLR8
Organism:
Homo sapiens (Human)

Structure

Length:
1041
Sequence:
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Cross Reference Drug Bank:
DB00724
Gene Ontology Go:
endolysosome membrane
endoplasmic reticulum membrane
endosome membrane
Golgi membrane
integral component of membrane
DNA binding
double-stranded RNA binding
drug binding
receptor activity
RNA binding
single-stranded RNA binding
cellular response to mechanical stimulus
defense response to virus
I-kappaB kinase/NF-kappaB signaling
immunoglobulin mediated immune response
inflammatory response
innate immune response
microglial cell activation
MyD88-dependent toll-like receptor signaling pathway
positive regulation of innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-8 biosynthetic process
regulation of cytokine secretion
regulation of protein phosphorylation
response to virus
toll-like receptor 8 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
Gene Ontology Biological Process:
cellular response to mechanical stimulus
defense response to virus
I-kappaB kinase/NF-kappaB signaling
immunoglobulin mediated immune response
inflammatory response
innate immune response
microglial cell activation
MyD88-dependent toll-like receptor signaling pathway
positive regulation of innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-8 biosynthetic process
regulation of cytokine secretion
regulation of protein phosphorylation
response to virus
toll-like receptor 8 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
Gene Ontology Molecular Function:
DNA binding
double-stranded RNA binding
drug binding
receptor activity
RNA binding
single-stranded RNA binding
Gene Ontology Cellular Component:
endolysosome membrane
endoplasmic reticulum membrane
endosome membrane
Golgi membrane
integral component of membrane
Keywords:
3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Leucine-rich repeat
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11022119 11022120 18810425 19924287 12975309 15772651 15489334 17932028 19159218 23520111