Names & Taxonomy
- Uniprot ID:
- Q9NQ25
- Entry Name:
- SLAF7_HUMAN
- Status:
- reviewed
- Protein Names:
- SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319)
- Gene Names:
- SLAMF7 CS1 UNQ576/PRO1138
- Gene Names Orf:
- UNQ576/PRO1138
- Gene Names Primary:
- SLAMF7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 335
- Sequence:
- MAGSPTCLTLIYILWQLTGSAASGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGAADDPDSSMVLLCLLLVPLLLSLFVLGLFLWFLKRERQEEYIEEKKRVDICRETPNICPHSGENTEYDTIPHTNRTILKEDPANTVYSTVEIPKKMENPHSLLTMPDTPRLFAYENVI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
- Cross Reference Drug Bank:
- DB06317
- Gene Ontology Go:
- integral component of membrane
plasma membrane
adaptive immune response
cell adhesion
natural killer cell activation
natural killer cell mediated cytotoxicity
regulation of immune response - Gene Ontology Biological Process:
- adaptive immune response
cell adhesion
natural killer cell activation
natural killer cell mediated cytotoxicity
regulation of immune response - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Adaptive immunity
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunity
Immunoglobulin domain
Innate immunity
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix