Names & Taxonomy
- Uniprot ID:
- Q9NPD5
- Entry Name:
- SO1B3_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
- Gene Names:
- SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8
- Gene Names Primary:
- SLCO1B3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 702
- Sequence:
- MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane; Multi-pass membrane protein.
Function
- Function:
- Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
- Cross Reference Drug Bank:
- DB06403 DB01076 DB06772 DB00520 DB08862 DB02659 DB01211 DB05239 DB00286 DB08912 DB09102 DB00390 DB01248 DB00783 DB00950 DB01095 DB08884 DB09054 DB00451 DB00279 DB01583 DB00563 DB00688 DB00275 DB01092 DB01229 DB01132 DB08860 DB00175 DB01045 DB08864 DB01098 DB09292 DB11362 DB00177
- Gene Ontology Go:
- basolateral plasma membrane
integral component of plasma membrane
plasma membrane
bile acid transmembrane transporter activity
organic anion transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
bile acid and bile salt transport
bile acid metabolic process
organic anion transport
small molecule metabolic process
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Biological Process:
- bile acid and bile salt transport
bile acid metabolic process
organic anion transport
small molecule metabolic process
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Molecular Function:
- bile acid transmembrane transporter activity
organic anion transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport