Names & Taxonomy
- Uniprot ID:
- Q9NP58
- Entry Name:
- ABCB6_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-binding cassette sub-family B member 6, mitochondrial (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter)
- Gene Names:
- ABCB6 MTABC3 PRP UMAT
- Gene Names Primary:
- ABCB6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 842
- Sequence:
- MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.
- Gene Ontology Go:
- ATP-binding cassette (ABC) transporter complex
endoplasmic reticulum
endoplasmic reticulum membrane
endosome
endosome membrane
extracellular exosome
Golgi apparatus
Golgi membrane
integral component of mitochondrial outer membrane
mitochondrial envelope
mitochondrial inner membrane
mitochondrial outer membrane
mitochondrion
plasma membrane
ATP binding
efflux transmembrane transporter activity
heme binding
heme transporter activity
heme-transporting ATPase activity
brain development
cellular iron ion homeostasis
heme transport
porphyrin-containing compound biosynthetic process
skin development
transmembrane transport
transport - Gene Ontology Biological Process:
- brain development
cellular iron ion homeostasis
heme transport
porphyrin-containing compound biosynthetic process
skin development
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATP binding
efflux transmembrane transporter activity
heme binding
heme transporter activity
heme-transporting ATPase activity - Gene Ontology Cellular Component:
- ATP-binding cassette (ABC) transporter complex
endoplasmic reticulum
endoplasmic reticulum membrane
endosome
endosome membrane
extracellular exosome
Golgi apparatus
Golgi membrane
integral component of mitochondrial outer membrane
mitochondrial envelope
mitochondrial inner membrane
mitochondrial outer membrane
mitochondrion
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Dyskeratosis congenita
Endoplasmic reticulum
Endosome
Golgi apparatus
Membrane
Microphthalmia
Mitochondrion
Mitochondrion outer membrane
Nucleotide-binding
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport