Names & Taxonomy
- Uniprot ID:
- Q9NP56
- Entry Name:
- PDE7B_HUMAN
- Status:
- reviewed
- Protein Names:
- cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.53)
- Gene Names:
- PDE7B
- Gene Names Primary:
- PDE7B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 450
- Sequence:
- MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
- Proteomes:
- UP000005640
Function
- Function:
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.
- Pathway:
- Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
- Catalytic Activity:
- Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and milrinone.
- Active Site:
- ACT_SITE 173 173 Proton donor.
- Cross Reference Drug Bank:
- DB00201 DB00651 DB00920
- Gene Ontology Go:
- cytosol
3',5'-cyclic-AMP phosphodiesterase activity
metal ion binding
cAMP catabolic process
signal transduction
synaptic transmission - Gene Ontology Biological Process:
- cAMP catabolic process
signal transduction
synaptic transmission - Gene Ontology Molecular Function:
- 3',5'-cyclic-AMP phosphodiesterase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Reference proteome
cAMP