Names & Taxonomy

Uniprot ID:
Q9NP56
Entry Name:
PDE7B_HUMAN
Status:
reviewed
Protein Names:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.53)
Gene Names:
PDE7B
Gene Names Primary:
PDE7B
Organism:
Homo sapiens (Human)

Structure

Length:
450
Sequence:
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
Proteomes:
UP000005640

Function

Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.
Pathway:
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Catalytic Activity:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
Cofactor:
COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and milrinone.
Active Site:
ACT_SITE 173 173 Proton donor.
Cross Reference Drug Bank:
DB00201 DB00651 DB00920
Gene Ontology Go:
cytosol
3',5'-cyclic-AMP phosphodiesterase activity
metal ion binding
cAMP catabolic process
signal transduction
synaptic transmission
Gene Ontology Biological Process:
cAMP catabolic process
signal transduction
synaptic transmission
Gene Ontology Molecular Function:
3',5'-cyclic-AMP phosphodiesterase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Reference proteome
cAMP

Publication

PubMed ID:
10814504 10872825 14574404 15489334 19690332