Names & Taxonomy
- Uniprot ID:
- Q9HCX4
- Entry Name:
- TRPC7_HUMAN
- Status:
- reviewed
- Protein Names:
- Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7)
- Gene Names:
- TRPC7 TRP7
- Gene Names Primary:
- TRPC7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 862
- Sequence:
- MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
- Gene Ontology Go:
- cis-Golgi network
integral component of plasma membrane
nuclear envelope
perinuclear region of cytoplasm
plasma membrane
store-operated calcium channel activity
axon guidance
blood coagulation
calcium ion transmembrane transport
ion transmembrane transport
manganese ion transport
platelet activation
regulation of cytosolic calcium ion concentration
single fertilization
transmembrane transport - Gene Ontology Biological Process:
- axon guidance
blood coagulation
calcium ion transmembrane transport
ion transmembrane transport
manganese ion transport
platelet activation
regulation of cytosolic calcium ion concentration
single fertilization
transmembrane transport - Gene Ontology Molecular Function:
- store-operated calcium channel activity
- Gene Ontology Cellular Component:
- cis-Golgi network
integral component of plasma membrane
nuclear envelope
perinuclear region of cytoplasm
plasma membrane - Keywords:
- ANK repeat
Alternative splicing
Calcium
Calcium channel
Calcium transport
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport