Names & Taxonomy

Uniprot ID:
Q9HCP6
Entry Name:
HHATL_HUMAN
Status:
reviewed
Protein Names:
Protein-cysteine N-palmitoyltransferase HHAT-like protein (Glycerol uptake/transporter homolog) (Hedgehog acyltransferase-like protein)
Gene Names:
HHATL C3orf3 GUP1 KIAA1173
Gene Names Primary:
HHATL
Organism:
Homo sapiens (Human)

Structure

Length:
504
Sequence:
MGIKTALPAAELGLYSLVLSGALAYAGRGLLEASQDGAHRKAFRESVRPGWEYIGRKMDVADFEWVMWFTSFRNVIIFALSGHVLFAKLCTMVAPKLRSWMYAVYGALAVMGTMGPWYLLLLLGHCVGLYVASLLGQPWLCLGLGLASLASFKMDPLISWQSGFVTGTFDLQEVLFHGGSSFTVLRCTSFALESCAHPDRHYSLADLLKYNFYLPFFFFGPIMTFDRFHAQVSQVEPVRREGELWHIRAQAGLSVVAIMAVDIFFHFFYILTIPSDLKFANRLPDSALAGLAYSNLVYDWVKAAVLFGVVNTVACLDHLDPPQPPKCITALYVFAETHFDRGINDWLCKYVYNHIGGEHSAVIPELAATVATFAITTLWLGPCDIVYLWSFLNCFGLNFELWMQKLAEWGPLARIEASLSVQMSRRVRALFGAMNFWAIIMYNLVSLNSLKFTELVARRLLLTGFPQTTLSILFVTYCGVQLVKERERTLALEEEQKQDKEKPE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
perinuclear region of cytoplasm
negative regulation of N-terminal protein palmitoylation
Gene Ontology Biological Process:
negative regulation of N-terminal protein palmitoylation
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
perinuclear region of cytoplasm
Keywords:
Complete proteome
Endoplasmic reticulum
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11374908 15489334 10574461