Names & Taxonomy
- Uniprot ID:
- Q9HBX9
- Entry Name:
- RXFP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1)
- Gene Names:
- RXFP1 LGR7
- Gene Names Primary:
- RXFP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 757
- Sequence:
- MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
- Gene Ontology Go:
- integral component of membrane
plasma membrane
G-protein coupled receptor activity
metal ion binding - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
metal ion binding - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Leucine-rich repeat
Membrane
Metal-binding
Receptor
Reference proteome
Repeat
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P24588