Names & Taxonomy
- Uniprot ID:
- Q9HBH5
- Entry Name:
- RDH14_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2) (Short chain dehydrogenase/reductase family 7C member 4)
- Gene Names:
- RDH14 PAN2 SDR7C4 UNQ529/PRO1072
- Gene Names Orf:
- UNQ529/PRO1072
- Gene Names Primary:
- RDH14
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 336
- Sequence:
- MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK
- Proteomes:
- UP000005640
Function
- Function:
- Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.
- Active Site:
- ACT_SITE 217 217 Proton acceptor.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
lysosomal membrane
membrane
mitochondrion
nucleus
alcohol dehydrogenase (NADP+) activity
osteoblast differentiation
retinol metabolic process - Gene Ontology Biological Process:
- osteoblast differentiation
retinol metabolic process - Gene Ontology Molecular Function:
- alcohol dehydrogenase (NADP+) activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
lysosomal membrane
membrane
mitochondrion
nucleus - Keywords:
- Complete proteome
NADP
Oxidoreductase
Phosphoprotein
Reference proteome