Names & Taxonomy
- Uniprot ID:
- Q9HAW8
- Entry Name:
- UD110_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 1-10 (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) (UDP-glucuronosyltransferase 1A10)
- Gene Names:
- UGT1A10 GNT1 UGT1
- Gene Names Primary:
- UGT1A10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 530
- Sequence:
- MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome. Endoplasmic reticulum membrane
Function
- Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Cross Reference Drug Bank:
- DB00316 DB00749 DB00678 DB00688 DB00313
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
enzyme binding
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
protein kinase C binding
cellular glucuronidation
flavone metabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
xenobiotic glucuronidation - Gene Ontology Biological Process:
- cellular glucuronidation
flavone metabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
xenobiotic glucuronidation - Gene Ontology Molecular Function:
- enzyme binding
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
protein kinase C binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix