Names & Taxonomy

Uniprot ID:
A4D1Q0
Entry Name:
A4D1Q0_HUMAN
Status:
unreviewed
Protein Names:
Muscarinic acetylcholine receptor
Gene Names:
CHRM2 hCG_1641225 tcag7.414
Gene Names Orf:
hCG_1641225 tcag7.414
Gene Names Primary:
CHRM2
Organism:
Homo sapiens (Human)

Structure

Length:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
Gene Ontology Go:
asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
neuronal cell body
postsynaptic membrane
symmetric synapse
drug binding
G-protein coupled acetylcholine receptor activity
regulation of heart contraction
regulation of smooth muscle contraction
Gene Ontology Biological Process:
regulation of heart contraction
regulation of smooth muscle contraction
Gene Ontology Molecular Function:
drug binding
G-protein coupled acetylcholine receptor activity
Gene Ontology Cellular Component:
asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
neuronal cell body
postsynaptic membrane
symmetric synapse
Keywords:
Cell junction
Cell membrane
G-protein coupled receptor
Membrane
Postsynaptic cell membrane
Receptor
Synapse
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11181995 12690205