Names & Taxonomy
- Uniprot ID:
- Q9H3S4
- Entry Name:
- TPK1_HUMAN
- Status:
- reviewed
- Protein Names:
- Thiamin pyrophosphokinase 1 (hTPK1) (EC 2.7.6.2) (Placental protein 20) (PP20) (Thiamine pyrophosphokinase 1)
- Gene Names:
- TPK1
- Gene Names Primary:
- TPK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 243
- Sequence:
- MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
- Pathway:
- Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.
- Catalytic Activity:
- ATP + thiamine = AMP + thiamine diphosphate.
- Cross Reference Drug Bank:
- DB00152
- Gene Ontology Go:
- cytosol
ATP binding
kinase activity
thiamine binding
thiamine diphosphokinase activity
small molecule metabolic process
thiamine diphosphate biosynthetic process
thiamine metabolic process
thiamine-containing compound metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- small molecule metabolic process
thiamine-containing compound metabolic process
thiamine diphosphate biosynthetic process
thiamine metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- ATP binding
kinase activity
thiamine binding
thiamine diphosphokinase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Disease mutation
Kinase
Nucleotide-binding
Reference proteome
Transferase