Names & Taxonomy
- Uniprot ID:
- Q9H3N8
- Entry Name:
- HRH4_HUMAN
- Status:
- reviewed
- Protein Names:
- Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144)
- Gene Names:
- HRH4 GPCR105
- Gene Names Primary:
- HRH4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
- Cross Reference Drug Bank:
- DB00321 DB00543 DB00477 DB00363 DB01142 DB00667 DB00408 DB06148 DB00334
- Gene Ontology Go:
- integral component of membrane
plasma membrane
synapse
G-protein coupled acetylcholine receptor activity
histamine receptor activity
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
inflammatory response
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of MAPK cascade
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
inflammatory response
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of MAPK cascade
synaptic transmission, cholinergic - Gene Ontology Molecular Function:
- G-protein coupled acetylcholine receptor activity
histamine receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane
synapse - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix