Names & Taxonomy

Uniprot ID:
Q9H3N8
Entry Name:
HRH4_HUMAN
Status:
reviewed
Protein Names:
Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144)
Gene Names:
HRH4 GPCR105
Gene Names Primary:
HRH4
Organism:
Homo sapiens (Human)

Structure

Length:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Cross Reference Drug Bank:
DB00321 DB00543 DB00477 DB00363 DB01142 DB00667 DB00408 DB06148 DB00334
Gene Ontology Go:
integral component of membrane
plasma membrane
synapse
G-protein coupled acetylcholine receptor activity
histamine receptor activity
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
inflammatory response
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of MAPK cascade
synaptic transmission, cholinergic
Gene Ontology Biological Process:
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
inflammatory response
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of MAPK cascade
synaptic transmission, cholinergic
Gene Ontology Molecular Function:
G-protein coupled acetylcholine receptor activity
histamine receptor activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
synapse
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10973974 11118334 11179434 11181941 11179436 12503632 18452403 16177791 15489334