Names & Taxonomy

Uniprot ID:
Q9H2X9
Entry Name:
S12A5_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter)
Gene Names:
SLC12A5 KCC2 KIAA1176
Gene Names Primary:
SLC12A5
Organism:
Homo sapiens (Human)

Structure

Length:
1139
Sequence:
MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262).
Enzyme Regulation:
ENZYME REGULATION: Inhibited by WNK3.
Cross Reference Drug Bank:
DB00887 DB00761
Gene Ontology Go:
dendritic shaft
integral component of membrane
integral component of plasma membrane
neuronal cell body
plasma membrane
chloride transmembrane transporter activity
potassium ion symporter activity
potassium:chloride symporter activity
protein kinase binding
cellular chloride ion homeostasis
cellular ion homeostasis
dendritic spine development
ion transport
learning
multicellular organism growth
potassium ion transmembrane transport
response to drug
synaptic transmission
thermosensory behavior
transmembrane transport
transport
Gene Ontology Biological Process:
cellular chloride ion homeostasis
cellular ion homeostasis
dendritic spine development
ion transport
learning
multicellular organism growth
potassium ion transmembrane transport
response to drug
synaptic transmission
thermosensory behavior
transmembrane transport
transport
Gene Ontology Molecular Function:
chloride transmembrane transporter activity
potassium:chloride symporter activity
potassium ion symporter activity
protein kinase binding
Gene Ontology Cellular Component:
dendritic shaft
integral component of membrane
integral component of plasma membrane
neuronal cell body
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Disease mutation
Epilepsy
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
12106695 11780052 15489334 16344560 10574461 21613606 24668262 26333769 16959974 24928908 26528127