Names & Taxonomy
- Uniprot ID:
- Q9H2M3
- Entry Name:
- BHMT2_HUMAN
- Status:
- reviewed
- Protein Names:
- S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)
- Gene Names:
- BHMT2
- Gene Names Primary:
- BHMT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 363
- Sequence:
- MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLHMEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYKYQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGPEGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPLGFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSKPDF
- Proteomes:
- UP000005640
Function
- Function:
- Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.
- Pathway:
- Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.
- Catalytic Activity:
- S-methyl-L-methionine + L-homocysteine = 2 L-methionine.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00134
- Gene Ontology Go:
- cytosol
extracellular exosome
S-adenosylmethionine-homocysteine S-methyltransferase activity
S-methylmethionine-homocysteine S-methyltransferase activity
zinc ion binding
cellular nitrogen compound metabolic process
L-methionine salvage
S-adenosylmethionine metabolic process
S-methylmethionine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
L-methionine salvage
S-adenosylmethionine metabolic process
small molecule metabolic process
S-methylmethionine metabolic process
sulfur amino acid metabolic process - Gene Ontology Molecular Function:
- S-adenosylmethionine-homocysteine S-methyltransferase activity
S-methylmethionine-homocysteine S-methyltransferase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- Alternative splicing
Complete proteome
Metal-binding
Methyltransferase
Phosphoprotein
Reference proteome
Transferase
Zinc