Names & Taxonomy
- Uniprot ID:
- Q9H2H9
- Entry Name:
- S38A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-coupled neutral amino acid transporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)
- Gene Names:
- SLC38A1 ATA1 NAT2 SAT1 SNAT1
- Gene Names Primary:
- SLC38A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 487
- Sequence:
- MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=890 uM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.5)
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by potassium, choline ions and 2-methylamino-isobutyric acid (MeAIB) (By similarity). Inhibited by lithium and N-methyl-D-glucamine.
- Gene Ontology Go:
- extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
L-asparagine transmembrane transporter activity
L-glutamine transmembrane transporter activity
L-histidine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
sodium:amino acid symporter activity
amino acid transmembrane transport
amino acid transport
asparagine transport
glutamine transport
histidine transport
ion transport
L-histidine transmembrane transport
neurotransmitter uptake
neutral amino acid transport
organic acid transmembrane transport
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- amino acid transmembrane transport
amino acid transport
asparagine transport
glutamine transport
histidine transport
ion transport
L-histidine transmembrane transport
neurotransmitter uptake
neutral amino acid transport
organic acid transmembrane transport
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- L-asparagine transmembrane transporter activity
L-glutamine transmembrane transporter activity
L-histidine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
sodium:amino acid symporter activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Amino-acid transport
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q969F0