Names & Taxonomy
- Uniprot ID:
- Q9H255
- Entry Name:
- O51E2_HUMAN
- Status:
- reviewed
- Protein Names:
- Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor)
- Gene Names:
- OR51E2 PSGR
- Gene Names Primary:
- OR51E2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 320
- Sequence:
- MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702).
- Gene Ontology Go:
- integral component of membrane
plasma membrane
G-protein coupled receptor activity
olfactory receptor activity
signaling receptor activity
steroid hormone receptor activity
cellular response to fatty acid
detection of chemical stimulus involved in sensory perception of smell
positive regulation of blood pressure
positive regulation of renin secretion into blood stream
steroid hormone mediated signaling pathway - Gene Ontology Biological Process:
- cellular response to fatty acid
detection of chemical stimulus involved in sensory perception of smell
positive regulation of blood pressure
positive regulation of renin secretion into blood stream
steroid hormone mediated signaling pathway - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
olfactory receptor activity
signaling receptor activity
steroid hormone receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Olfaction
Receptor
Reference proteome
Sensory transduction
Transducer
Transmembrane
Transmembrane helix