Names & Taxonomy
- Uniprot ID:
- Q9H239
- Entry Name:
- MMP28_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin)
- Gene Names:
- MMP28 MMP25 UNQ1893/PRO4339
- Gene Names Orf:
- UNQ1893/PRO4339
- Gene Names Primary:
- MMP28
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 520
- Sequence:
- MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- Can degrade casein. Could play a role in tissues homeostasis and repair.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 241 241
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- cytoplasm
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
zinc ion binding
negative regulation of macrophage chemotaxis - Gene Ontology Biological Process:
- negative regulation of macrophage chemotaxis
- Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Calcium
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen